Low-intensity focused ultrasound (LIFU) is a promising non-invasive tool for targeting various brain regions including subcortical ones. The objective of this project (which is Ali Zadeh’s PhD project) is to understand how different LIFU settings impact the brain's response.

To accomplish this, Ali employs mathematical models and magnetic resonance imaging (MRI) scans, alongside transcranial magnetic stimulation (TMS) and EMG to investigate and measure the effects of LIFU on cortical excitability. His research also delves into examining the spatial selectivity of LIFU when stimulating the primary motor cortex. Ultimately, Ali's goal is to enhance LIFU as a valuable tool for both clinicians and scientists in the future.

Guided by his supervisor, Oury Monchi, and working closely with his co-supervisor, Samuel Pichardo, associate professor at the University of Calgary and the VP of Scientific Operations at NovusTX Devices, a Calgary-based startup, Ali is trying of advancing LIFU technology for neuromodulation.

This project is funded by an innovation CFI to Dr. Bruce Pike and collaborators as well as an NSERC discovery grant to Oury Monchi.